Protein Modification Reagents
Medchemexpress LLC DSPE-PEG-DBCO sodium | 95.0% | 5000 Da | C65H104N3O12P | 5 MG
DSPE-PEG-DBCO sodium (MW 5000) is a PEGylated phospholipid provided as the sodium salt and designed for surface functionalization of liposomes and nanoparticles and for copper-free bioconjugation using DBCO-azide chemistry. It is supplied as a solid for research applications and is intended for use in drug delivery and bioconjugation studies.
- Provides DBCO functional group for strain-promoted azide-alkyne cycloaddition (copper-free click chemistry).
- PEG spacer (≈5000 Da) offers steric stabilization and reduces opsonization.
- Sodium salt form, solid, suitable for incorporation into lipid formulations.
- Reported high purity (~95.0%) for research-grade applications.
- Available in small research quantities for formulation and conjugation studies.
Medchemexpress LLC Dbco-(PEG2-VC-PAB-MMAE)2 | 2259318-55-1 | 99.2% | 2,835.50 g/mol | C149H224N22O32 | 50 MG
DBCO-(PEG2-VC-PAB-MMAE)2 is a drug-linker conjugate for antibody-drug conjugate (ADC) research that combines a DBCO reactive group with a cleavable valine-citrulline linker, a p-aminobenzyl self-immolative spacer, and dual MMAE payloads. It is supplied as a purified powder for use in bio-conjugation via strain-promoted alkyne-azide cycloaddition (SPAAC).
- Provides a DBCO reactive group for copper-free click chemistry (SPAAC).
- Includes a PEG2 spacer for improved solubility and flexibility.
- Features a valine-citrulline cleavable linker with a p-aminobenzyl self-immolative spacer.
- Contains two MMAE payloads for potent cytotoxic delivery.
- High purity, typically 99.2%.
- Supplied as a powder suitable for ADC construction and conjugation.
Medchemexpress LLC Biotin-PEG4-PFP ester | 1334172-58-5 | 96.2% | 657.65 g/mol | C27H36F5N3O8S | 5 MG
Biotin-PEG4-PFP ester is a biotinylated, cleavable PEG-based linker containing a pentafluorophenyl activated ester for efficient coupling to primary amines. It is used in antibody-drug conjugate (ADC) synthesis, PROTAC linker construction, and the biotinylation of proteins or small molecules. The reagent is supplied as a powder and requires low-temperature storage to maintain stability.
- Biotinylated PEG4 spacer with pentafluorophenyl activated ester.
- Suitable for coupling to primary amines in proteins and small molecules.
- Used as an ADC and PROTAC linker or biotinylation reagent.
- High purity and defined storage conditions for stability.
- Available in small milligram quantities for research use.
Medchemexpress LLC Mal-amido-PEG6-NHS ester | 1137109-21-7 | 98.8% | 601.60 | 500 MG
Mal-amido-PEG6-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein. They exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
STA PHARMACEUTICAL US LLC Fmoc-NH-PEG8-CH2COOH | 50 g | CAS 868594-52-9 | MDL MFCD27635163
Fmoc-NH-PEG8-CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 50 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 868594-52-9
- MDL: MFCD27635163
- InChIKey: JRLUSGRARXJCNA-UHFFFAOYSA-N
- Molecular Weight: 649.734
- Molecular Formula: C33H47NO12
- Purity: ≥95%
- Container Type: 250 mL HDPE
- Pack Size: 50 g
- Net Weight: 50 g
- Gross Weight: 89.8 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28-nonaoxa-4-azatriacontan-30-oic acid
- SMILES: O=C(COCCOCCOCCOCCOCCOCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O
Medchemexpress LLC Dspe-peg-oh | 99.89% | 100 MG
DSPE-PEG-OH (MW 2000) is a hydroxyl-terminated PEGylated phospholipid. Its hydrophobic tail allows for the encapsulation and aggregation of other hydrophobic drugs, and its hydroxyl terminus is suitable for further reactions. DSPE-PEG-OH (MW 2000) can be used to prepare liposomes or lipid nanoparticles.
- Hydroxyl-terminated PEGylated phospholipid.
- Hydrophobic tail enables encapsulation and aggregation of other hydrophobic drugs.
- Hydroxyl terminus suitable for further reactions.
- Can be used to prepare liposomes or lipid nanoparticles.
Medchemexpress LLC Dspe-peg-fluor 647 | 95.4% | 5000 | 1 MG
DSPE-PEG-Fluor 647, MW 5000 is a PEGylated lipid with a DSPE group and a Fluor 647 fluorophore. DSPE is a phospholipid. Fluor 594 is a red water-soluble dye.
- Pegylated lipid
- Contains DSPE group and a Fluor 647 fluorophore
- DSPE is a phospholipid
- Fluor 594 is a red water-soluble dye
Medchemexpress LLC DMG-PEG-Mal (MW 2000) | 99.3% | 2000 (Average) | 5 MG
DMG-PEG-Mal (MW 2000) is a PEG lipid designed to enhance the delivery efficiency and tissue specificity of poorly soluble drugs. This compound is valuable for various drug delivery research applications.
- Improves delivery efficiency of poorly soluble drugs
- Enhances tissue specificity
- Suitable for drug delivery research
Medchemexpress LLC Mal-PEG4-Val-Cit-PAB-MMAE | 98.0% | 1450.76 | C73H115N11O19 | 5 MG
Mal-PEG4-Val-Cit-PAB-MMAE is a cleavable drug-linker conjugate used for antibody-drug conjugate research. It combines a maleimide-terminated PEG4 spacer, a Val-Cit-PAB cleavable dipeptide linker, and the tubulin inhibitor MMAE, supplied as a high-purity material for linker-payload conjugation and analytical characterization.
- Cleavable Val-Cit-PAB linker designed for enzymatic release in lysosomes.
- Maleimide-terminated PEG4 spacer for thiol conjugation.
- Contains MMAE payload for potent antimitotic activity.
- High reported purity enabling reliable conjugation and analysis.
- Pack sizes suitable for small-scale research and method development.
Medchemexpress LLC Methyl-PEG4-NHS ester | 622405-78-1 | MFCD11041112 | 95.0% | 333.33 | C14H23NO8 | 10G
Methyl-PEG4-NHS ester is a methyl-capped polyethylene glycol linker terminating in an N-hydroxysuccinimide (NHS) ester. It is used for amine-targeted bioconjugation and as a flexible PEG spacer in bifunctional molecules, enabling efficient formation of stable amide bonds and improved solubility.
- Provides an NHS ester for rapid conjugation to primary amines.
- Methyl-capped PEG4 spacer increases solubility and linker flexibility.
- Suitable for PROTAC synthesis and general bioconjugation applications.
- Molecular weight 333.33 and molecular formula C14H23NO8.
- CAS number 622405-78-1 and MFCD11041112 for reference.
- Typical purity around 95.0% and available in multiple pack sizes.
![eMolecules Broadpharm / t-Boc-N-amido-PEG16-acid / 250mg / 713699783 / BP-28089 / 98.000 / / [null] / 894.059 / C40H79NO20](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502475005.JPG-250.jpg)
eMolecules Broadpharm / t-Boc-N-amido-PEG16-acid / 250mg / 713699783 / BP-28089 / 98.000 / / [null] / 894.059 / C40H79NO20
Broadpharm / t-Boc-N-amido-PEG16-acid / 250mg / 713699783 / BP-28089 / 98.000 / / [null] / 894.059 / C40H79NO20